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Activation of BMP3 to Treat Pulmonary Hypertension
THE CHALLENGE
The major business challenge in addressing pulmonary arterial hypertension (PAH) lies in the urgent need for breakthrough therapies that go beyond symptom management to truly modify disease progression. Current drugs offer limited clinical benefit, are burdened by significant side effects, and fail to reverse the underlying biological...
Published: 10/8/2025
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Inventor(s): Yassine Sassi, Aymen Halouani
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Temporally Patterned Simulation Script/Algorithm/Software for the Treatment of Brain Injury, Neurodegenerative Diseases, and Psychiatric Disorders
THE CHALLENGE
The key challenge associated with stimulation based neurological treatment lies in bridging the gap between cutting-edge neuroscience and the current limitations of commercial neuromodulation devices, which largely rely on outdated, fixed-frequency stimulation protocols. Despite mounting evidence that the brain’s response to therapy...
Published: 10/8/2025
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Inventor(s): Michael Friedlander, Quentin Fischer, Djanenkhodja Kalikulov, Carrie Williams, Philip Baldwin, Gonzalo Di Prisco
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Software
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Droplet-Based Single-Cell Epigenomic Assay
THE CHALLENGE
A major challenge in single-cell DNA methylation profiling lies in the inefficiency and high cost of current methods, which rely on labor-intensive, plate- or tube-based workflows that are difficult to scale. These traditional approaches not only require multiple manual steps and expensive reagents but also suffer from significant DNA...
Published: 10/8/2025
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Inventor(s): Chang Lu, Qiang Zhang
Keywords(s):
Category(s): Technology Classifications > Biotechnology, Technology Classifications > Biomedical
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Octopus-Mimetic Adhesives for Wet Surface Attachment
THE CHALLENGE
The challenge in creating effective underwater adhesion systems lies in bridging a critical gap between advanced materials science and real-world usability, especially for industries like marine robotics, offshore maintenance, and biomedical handling. Traditional solutions either bond too permanently, require ideal flat surfaces, consume...
Published: 10/8/2025
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Inventor(s): Michael Bartlett, Chanhong Lee
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Robotics
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High-Efficiency CRISPR Editing in Mammalian Zygotes
THE CHALLENGE
The major challenge in developing reliable gene editing solutions for livestock lies in delivering CRISPR reagents efficiently into mammalian zygotes without harming embryo viability, an issue that significantly limits scalability, consistency, and commercial viability. Traditional methods like microinjection are technically challenging,...
Published: 8/5/2025
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Inventor(s): Fernando Biase
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology
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Implant for Plantar Plate Repair
THE CHALLENGE
The plantar plate is a deep fibrocartilaginous structure found in the foot whose primary role is to stabilize metatarsophalangeal joints and other structures; unfortunately, it can tear when inflamed or overworked as a result of running or other activities. Other than pain and discomfort, plantar plate tears can also cause the second...
Published: 8/5/2025
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Inventor(s): Demitria Poulos, Logan Dickinson, Skye Carlson, Zachary Kozar, Jennifer Wayne, Vincent Wang, John Clements
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Medical Devices
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Robotic Tail Used to Improve Performance and Stability of Mobile Robots
THE CHALLENGE
Natural and man-made disasters are becoming more and more commonplace. As these disasters increase in number, so does the need for, and risk to, first responders who search through rubble and rescue survivors. In response to these increased risks, legged mobile robots have emerged as a first response option as they can maneuver over...
Published: 8/5/2025
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Inventor(s): Pinhas Ben-Tzvi, Wael Saab, William Rone
Keywords(s):
Category(s): Technology Classifications > Engineering, Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Electronics, Technology Classifications > Medical Devices
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Genomic and Proteomic Biomarkers for Heifer Fertility
THE CHALLENGE
Fertility is a critical factor in livestock breeding, directly impacting the productivity and economic viability of beef and dairy operations. Each year, more than 750,000 beef heifers and 210,000 dairy heifers fail to produce calves despite multiple breeding attempts using artificial insemination or bull exposure. These sub-fertile or...
Published: 10/8/2025
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Inventor(s): Fernando Biase
Keywords(s):
Category(s): Technology Classifications > Biomedical
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Wireless Acoustofluidic System for Remote Manipulation of Nanoparticles and Cells
THE CHALLENGE:
Acoustofluidics, the integration of acoustic waves with microfluidic systems, plays a crucial role in manipulating particles and cells for applications in biomedical research, diagnostics, and lab-on-a-chip technologies. This technology enables precise control over fluid flow, particle concentration, and cell alignment without physical...
Published: 5/21/2025
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Inventor(s): Zhenhua Tian, Jiali Li, Luyu Bo, Teng Li
Keywords(s):
Category(s): Technology Classifications > Biomedical
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SonicSurf Manipulator
THE CHALLENGE
Developing advanced contactless manipulation technologies lies in creating a solution that is not only technically effective but also scalable, affordable, and easy to integrate into real-world biomedical and chemical workflows. Current methods—like optical tweezers, magnetic actuators, and traditional acoustic systems—are...
Published: 10/8/2025
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Inventor(s): Zhenhua Tian, Teng Li, Jiali Li, Luyu Bo
Keywords(s):
Category(s): Technology Classifications > Biomedical, Technology Classifications > Chemicals/Materials, Technology Classifications > Engineering
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